Because of the similarity in functionality between human and canine Mast cells, Roxy’s Remedies believes the human research and safety data is relevant to health professionals and consumers seeking a natural alternative for their pets’ health.
Sandalwood oil has been shown to inhibit the growth of many pathogenic bacteria, including those commonly found on the skin and even strains that are resistant to antibiotics,3, 4 including methicillin-resistant Staphylococcus aureus (MRSA) and Propionibacterium acnes.
Sandalwood oil has also been shown extremely effective in preventing the growth of fungi that cause many skin problems in humans. These fungi are known as dermatophytes and are responsible for many problem conditions of the skin, hair and nails. This class of microorganisms includes Epidermophyton inguinale, Trichophyton interdigitale, Trichophyton rubrum, Trichophyton asteroides, and Achorion gypseum, among others.5,12
Concentrations of sandalwood oil as low as 0.0005% have been shown to completely inhibit the growth of the fungi responsible for athlete’s foot, nail fungus and other skin disease in humans.
Sandalwood oil has been shown to be an inhibitor of several enzymes that play a role in inflammation in human skin. The inflammatory pathway enzymes Cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and 12-lipoxygenase were all inhibited by the oil. These enzymes are the same ones through which other anti-inflammatory drugs, such as aspirin, are known to exert their effects on inflammation. Anecdotal evidence also suggests that the oil is effective in reducing the erythema caused by exposure to UV light (sunburn).3
Activity against Viruses
Sandalwood oil has been demonstrated to inhibit herpes virus types 1 and 2. It has also been proven in human clinical trials to be active against warts caused by human papillomavirus (HPV).6, 7, 8,9,10
In addition to its anti-inflammatory properties, sandalwood oil has also been shown to induce to the production of glutathione-S-transferase (GST) and acts as an antioxidant.11, 12
- Burdock G., Carabin I. Safety Assessment of sandalwood oil (Santalum album L) Food and Chemical Technology 2008;46:421-432
- Sindhu R., Upma, Kumar A., Arora S. Santalum album Linn: A review on morphology, phytochemistry and pharmacological aspects. International Journal of PharmTech Research 2010;2:914-919
- Priest D. Un potente antibatterico e anti-infiammatorio natural derivato dal legno di sandal Australiano per cosmetici e personal care. Cosmetic News 2004;155:107-109
- Warnke P., Becker S., Podschun R., Sivananthan S., Springer I., Russo P., Wiltfang J., Fickenscher H., Sherry E. The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections. Journal of Cranio-Maxillofacial Surgery 2009;37:392-397
- Okazaki K., Oshima S. Antibacterial activity of higher plants. XXIV. Antimicrobial effect of essential oils. (5). Yakugaku Zasshi 1953;73:344-347
- Benencia F, Courreges MC. 1999. Antiviral activity of sandalwood oil against herpes simplex viruses-1 and -2. Phytomedicine 1999;6:119–123
- Koch C., Reichling J., Schneele J., Schnitzler P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine 2008;15:71-78
- Schnitzler P, Koch C, Reichling J. Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood. Antimicrob Agents Chemother 2007;51(5):1859–1862
- Haque et al. US Patent No 6,406,706 B1. Use of α- and β-santalols major constituents of sandalwood oil, in the treatment of warts, skin blemishes and other viral-induced tumors. June 18, 2002
- Haque M., Haque A. Use of sandalwood oil for the prevention and treatment of warts, skin blemishes and other viral-induced tumors. US patent 6,132,756. 17 Oct 2000
- Scartezzini P., Speroni E. Review on some plants of Indian traditional medicine with antioxidant activity. Journal of Ethnopharmacology 2000;71:23-43
- Inouye S., Takahashi M., Abe S. Composition, antifungal and radical scavenging activities of 15 rare essential oils. International Journal of Essential Oil Therapeutics 2010;4:1-10